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Effect of Lymphocyte Depletion by Thoracic Duct Fistula and Administration of Antilymphocytic Serum on the Survival of Skin Homografts in Rats

Nature volume 200, page 702 (1963)Cite this article

Abstract

SINCE lymphocytes appear to play a crucial part in the homograft reaction it seemed of interest to examine the behaviour of homografts in recipients subjected to chronic lymphocyte depletion by: (a) drainage of lymph through a thoracic duct fistula; (b) repeated administration of a hetero-specific antilymphocytic serum; (c) a combination of these procedures.

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References

  1. Gowans, J. L.,, McGregor, D. D., Cowen, D. M., and Ford, C. E., Nature, 196, 651 (1962).

    Article  ADS  CAS  Google Scholar 

  2. Woodruff, M. F. A., The Transplantation of Tissues and Organs (C. C. Thomas, Springfield, Ill., 1960).

    Google Scholar 

  3. Woodruff, M. F. A., and Simpson, L. O., Plast. Reconstr. Surg., 15, 451 (1955).

    Article  CAS  Google Scholar 

  4. Bollman, J. L., Cain, J. C., and Grindlay, J. H., J. Lab. Clin. Med., 33, 1349 (1948).

    CAS  PubMed  Google Scholar 

  5. Gowans, J. L., Brit. J. Exp. Path., 38, 67 (1957).

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Surgical Science, University of Edinburgh, and Medical Research Council Research Group on Clinical and Experimental Problems of Transplantation,

    M. F. A. WOODRUFF & N. A. ANDERSON

Authors
  1. M. F. A. WOODRUFF
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  2. N. A. ANDERSON
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WOODRUFF, M., ANDERSON, N. Effect of Lymphocyte Depletion by Thoracic Duct Fistula and Administration of Antilymphocytic Serum on the Survival of Skin Homografts in Rats. Nature 200, 702 (1963). https://doi.org/10.1038/200702a0

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