Open Source Linux Medical Software

These R packages are developed for data analysis of PK/PD modeling & simulation, bioequivalence/bioavailability (BE/BA), drug stability, in-vitro and in-vivo correlation (ivivc), as well as therapeutic drug monitoring (TDM).

Model-based Analysis of Genome-wide CRISPR-Cas9 Knockout (MAGeCK) is a computational tool to identify important genes from the recent genome-scale CRISPR-Cas9 knockout screens technology. For instructions and documentations, please refer to the wiki page. MAGeCK is developed by Wei Li and Han Xu from Dr. Xiaole Shirley Liu's lab at Dana-Farber Cancer Institute/Harvard School of Public Health, and is maintained by Wei Li lab at Children's National Medical Center. We thank the support from Claudia Adams Barr Program in Innovative Basic Cancer Research and NIH/NHGRI to develop MAGeCK.

This program was developed as a help in establishing pharmaceutical equivalence by use of FDA f2 coefficient. It was designed to help with f2 computation in cases when intra- and inter-batch variability is large, namely RSD>10%. The use of statistical bootstrap technique allows to implement confidence interval (CI) into the f2 coefficients resulting in overcoming of their major drawback in the original metrics. The algorithm provides possible “worst case scenario” of f2 values, thus supporting claim about pharmaceutical equivalence. The target users are researchers from industry and academia dealing with pharmaceutical equivalence problem. The software is Open Source. It was developed in Lazarus environment, therefore source code is available in ObjectPascal.

This is a sophisticated & integrated simulation and analysis environment for dynamical systems models of physical systems (ODEs, DAEs, maps, and hybrid systems). It supports symbolic math, optimization, continuation, data analysis, biological apps...

Parallel Spectral Deconvolution is a multithreaded ImageJ plugin for spectral image deblurring.

The new version of MinimPy (MinimPy2) is available for download at: https://osdn.net/dl/minimpy2/MinimPy2.zip Please send your feedback about this new version to mahmood.saghaei@gmail.com (include MinimPy2 in the subject) ============================================================ MinimPy is a desktop application program for sequential allocation of subjects to treatment groups in clinical trials by using the method of minimization. Comprehensive reference help is available at http://minimpy.sourceforge.net MinimPy has been fully described in the following article: Saghaei, M. and Saghaei, S. (2011) Implementation of an open-source customizable minimization program for allocation of patients to parallel groups in clinical trials. Journal of Biomedical Science and Engineering, 4, 734-739. doi: 10.4236/jbise.2011.411090. Available at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=8518

Main application is twofold: first to convert genotype SNP data into formats of different imputation tools like PLINK MACH, IMPUTE, BEAGLE and BIMBBAM, second to transform imputed data into different file formats like PLINK, HAPLOVIEW, EIGENSOFT and SNPTEST. Readable file formats: plink-pedigree (ped and map), plink-raw, plink-dosage, mach , minimac, impute, snptest, beagle and bimbam. Similarly all kinds of imputation of outputs are also accepted. Formats which can be generated by fcGENE: plink-pedigree, plink-raw, plink-dosage, mach-inputs, minimac-inputs, impute-inputs, beagle-inputs and bimbam-inputs, HAPLOVIEW-inputs, EIGENSOFT-inputs. Further application: -obtaining templates of necessary imputation commands and commands of other imputation tool - Quality control according as MAF,HWE & CALLRATE. key words: genotype transformation, convert genotype format, imputation output, PLINK, IMPUTE, MACH, minimac, HAPLOVIEW, BEAGLE, BIMBAM,EIGENSOFT.

OpenCell is a user interface for working with CellML models. Features: * Integrate models made up of ODEs. * Supports CellML 1.0 and 1.1, allowing you to build complex models using imports. * Plot and edit graphs. * And more ...

Parallel Iterative Deconvolution is a multithreaded ImageJ plugin for iterative image deblurring.

SPINA is software for the rapid, reliable and accurate determination of constant structure parameters of endocrine feedback control systems. It is a class of static function tests that require nothing more than steady-state concentrations of hormones or metabolites obtained in vivo. The first version of this cybernetic approach had been developed for the evaluation of the functional status of the thyroid gland, i.e. thyroid's secretory capacity (gain of thyroid, GT or SPINA-GT) and sum activity of peripheral deiodinases (GD or SPINA-GD). A second version has been established for insulin-glucose homeostasis. It delivers the secretory capacity of pancreatic beta cells (SPINA-GBeta), an estimate for the insulin receptor amplification (SPINA-GR) and a static disposition index as a measure for the loop gain of the feedback loop (SPINA-DI). Both implementations of SPINA have been validated in more than 50 clinical studies based on large cohorts.

This will be a place to release tools that have not yet been added to SciPy (or will not be added for whatever reason). Currently an interface to ImageMagick is here.

MASyV (Multi-Agent System Visualization) enables one to write agent-based models/cellular automata, eg. in C, visualize them in real time & capture to movie file with MASyVs GUI & message passing lib. Includes examples: Hello World, ants, viral infection

The Biopsychology Nonlinear Toolbox is a MATLAB toolbox that combines established analysis routines in one easy to use graphical user interface.

DeDAY (Demography Data Analyses) is a tool of analyzing demography data. It supports Gompertz, Weibull and Logistic distributions. DeDay also supports mixed mortality models based on these distribution such as the Gompertz-Makeham distribution. Distributions such as Gompertz describes only age-dependent mortality, which increases over time. Mixed mortality models, such as in Gompertz-Makeham distribution, consider a more general case where mortality is consist of both age-dependent and in-dependent mortality. Mixed models partition mortality into exogenous and endogenous components, so that the intrinsic survivorship can be estimated without the interference from extrinsic noise. DeDAY supports both interval-censored data and exact event-time data. Using MLE (Maximum Likelihood Estimate), DeDAY fits statistic model to the data. DeDAY also calculates the variances and the multi-dimensional confidence limits of model parameters. DeDAY is free for academic users.

A topological data structure to handle 2D, surfaces and 3D simplicial meshes. This data structure is implemented in C++ using templates. It is based on Corner-Table and CGAL data structure.

Parallel HRRT Deconvolution is a multithreaded ImageJ plugin for motion correction of PET brain images.

PopED (Population Experimental Design) is a software tool for computing optimal experimental designs. The software has been developed with an emphasis on drug trials based on population models (non-linear mixed effects models).

A collection of code, bundled into a single R package, to perform several aspects of data management, image pre-processing, data analysis and statistical inference related to the quantitative analysis of dynamic contrast-enhanced MRI (DCE-MRI).

This project provides visual interactive interfaces to custom algorithms used in genomes research.

A program to model admixture using marker genotype data. Please visit http://homepages.ed.ac.uk/pmckeigu/admixmap/index.html for more information.

A java based neural network framework. The Auratus network is built around an XML messaging system, allowing for a complete MVC design. Additionally, Auratus networks are constructed and at the node/edge level, allowing for advanced topologies.

The purpose of the project is to develop a quantitative medical imaging & visualization program for use on brain MR, DTI and MRS data. It is a joint project of the Kennedy Krieger Institute & the Johns Hopkins University, Psychiatric Neuroimaging Lab

Research code for continuous 3D medial modeling targeted towards anatomical objects. Includes an OpenGL viewer and individual and population-based model fitting tools.

The continuous medial representation is a method for object representation and shape analysis. Hosted on Sourceforge are the source code for routines that fit medial models to anatomical objects.

A group of statistical tools used in the development and structuring of clinical trials by the American Cancer Society. Sample size calculators.