Best Endpoint Protection Software in the USA
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Compare the Top Endpoint Protection Software in the USA as of March 2026
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What is Endpoint Protection Software in the USA?
Endpoint protection software is a software platform that provides the solution to secure endpoints—such as laptops, desktops, smartphones, and tablets—against cyber threats and attacks. These platforms provide real-time monitoring and defense mechanisms to protect devices from malware, ransomware, phishing, and other types of threats. Endpoint protection software typically includes antivirus, anti-malware, firewall, encryption, and intrusion prevention features to prevent unauthorized access and ensure data security. It also allows for centralized management, enabling IT teams to enforce security policies, update software, and monitor the health of all devices in the network. By using endpoint protection software, organizations can safeguard their devices and networks from cyber risks while maintaining compliance with security standards. Compare and read user reviews of the best Endpoint Protection software in the USA currently available using the table below. This list is updated regularly.
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1
ManageEngine Endpoint Central
ManageEngine
ManageEngine Endpoint Central is built to secure the digital workplace while also giving IT teams complete control over their enterprise endpoints. It delivers a security-first approach by combining advanced endpoint protection with comprehensive management, allowing IT teams to manage the entire endpoint lifecycle, all from a single console. With automated patching across Windows, Mac, Linux and 1,000+ third-party applications, it ensures vulnerabilities are mitigated before attackers can exploit them. Its next-gen antivirus (NGAV) feature, powered by AI-driven behavioural detection, provides 24/7 protection against ransomware, malware, and zero-day threats. Endpoint Central further strengthens enterprise defenses with a broad set of security capabilities, including vulnerability assessment and mitigation, peripheral device control, data loss prevention, application control, endpoint privilege management, encryption with FileVault and BitLocker, and browser security.Starting Price: $795.00/one-time -
2
1Password
1Password
1Password is a secure, scalable, and easy-to-use password manager that's trusted by the world's leading companies. Using 1Password makes it easy for your employees to stay safe online. Once 1Password is part of their workflow, good security habits will become second nature. 1Password Advanced Protection is now available with 1Password Business. Set Master Password policies, enforce two-factor authentication team-wide, restrict access with firewall rules, review sign-in attempts and require your team to use the latest version of 1Password. Our award-winning apps are available for Mac, iOS, Linux, Windows, and Android. 1Password syncs seamlessly across devices, so your employees always have access to their passwords. When everyone uses 1Password, your risk goes down — and your productivity goes up.Starting Price: $3.99/month/user -
3
Guardz
Guardz
Guardz is the unified cybersecurity platform purpose-built for MSPs. We consolidate the essential security controls, including identities, endpoints, email, awareness, and more, into one AI-native framework designed for operational efficiency. Our identity-centric approach connects the dots across vectors, reducing the gaps that siloed tools leave behind so MSPs can see, understand, and act on user risk in real time. Backed by an elite research and threat hunting team, Guardz strengthens detection across environments, turning signals into actionable insights. With 24/7 AI + human-led MDR, Guardz utilizes agentic AI to triage at machine speed while expert analysts validate, mitigate, and guide response, giving MSPs scalable protection without adding headcount. Our mission is simple: give MSPs the scale, confidence, and clarity they need to stay ahead of attackers and deliver protection to every SMB they serve. -
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DriveStrike
DriveStrike
DriveStrike is easy to use, implement and manage. With DriveStrike you can execute secure remote wipe, remote lock, and remote locate commands on any platform. Integrated drive encryption support as well as mobile device management MDM for mobile platforms. Our professional support team is always available to answer your questions and help you install our services or manage your account and devices. Protecting your data and devices has never been easier or more cost effective. If you have questions or need help understanding how best to protect your data please contact us and we will gladly answer your questions. Protect your business with a device and data protection platform that keeps all devices safe with a single solution and Dashboard. Keep your Workstations, MacBooks, iPads, Smartphones, Tablets, Laptops safe, secure, and organized.Starting Price: $0.99 per month -
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ThreatLocker
ThreatLocker
The ThreatLocker suite of security tools are powerful and designed so that everyone from businesses to government agencies to academic institutions can directly control exactly what applications run on their networks. We envision a future in which all organizations can chart their own course free from the influence of cybercriminals and the damage their incursions cause, and our team of veteran cybersecurity professionals created ThreatLocker to make this vision a reality. The team at ThreatLocker has been developing cybersecurity tools for decades, including programs to enhance email and content security, and this is our most innovative and ambitious cybersecurity solution yet. We developed this unique cybersecurity system because we believe that organizations should have complete control of their networks and should not have to live in fear of the next malware attack. To learn more, visit ThreatLocker.com. -
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Airlock Digital
Airlock Digital
Airlock Digital is an application control solution that enforces a Deny by Default security posture. It enables organizations to define trusted applications, scripts, libraries, and processes at a granular level using file hash, path, publisher, or parent process. Only those explicitly defined as trusted are allowed to execute. The platform supports Windows, macOS, and Linux systems, including legacy operating systems and operational technology (OT) environments. Airlock Digital includes allowlisting and blocklisting capabilities, integrated file reputation checks via VirusTotal, and detailed logging for audit and compliance. Exception management is supported through features such as rule-based overrides and time-bound One-Time Passwords (OTPs). Centralized policy management allows consistent enforcement across large and distributed environments. The platform is available as an on-premises deployment, in the cloud, or as a managed hosted service. -
7
UTunnel VPN and ZTNA
Secubytes LLC
UTunnel provides Cloud VPN, ZTNA, and Mesh Networking solutions for secure remote access and seamless network connectivity. ACCESS GATEWAY: Our Cloud VPN as a Service offers swift deployment of Cloud or On-Premise VPN servers. It utilizes OpenVPN and IPSec protocols, enables policy-based access control, and lets you deploy a Business VPN network effortlessly. ONE-CLICK ACCESS: A Zero Trust Application Access (ZTAA) solution that simplifies secure access to internal business applications. It allows users to securely access them via web browsers without the need for a client application. MESHCONNECT: This Zero Trust Network Access (ZTNA) and mesh networking solution based on WireGuard enables granular access controls to business network resources and easy creation of secure mesh networks. SITE-TO-SITE VPN: The Access Gateway solution lets you easily set up secure Site-to-Site tunnels (IPSec) between UTunnel's VPN servers and hardware network gateways, firewalls & UTM systems.Starting Price: $6/user/month -
8
SafeDNS
SafeDNS
At SafeDNS, we are committed to creating a safer and more secure online environment for SMBs, enterprises, ISPs, MSPs, OEMs, and Education. We have a global footprint, making the internet safer for millions of users in over 60 countries. With years of experience in the field of cybersecurity and DNS filtering, we offer cutting-edge solutions to safeguard your digital life. At present, SafeDNS serves more than 4000 businesses and institutions, and tens of thousands of home users worldwide. We do: -Web content filtering. We help you block all dangerous or unwanted websites such as pornography, violence, child sexual abuse and similar categories. -Malware protection. We also have your back against malicious sites trying to breach user devices either with viruses or information theft intent. -Cloud service. Additionally, we provide you with a cloud filtering service that requires no additional hardware purchase or software installation.Starting Price: $0.9/user/month -
9
Syncro
Syncro
Syncro offers the first Extended Monitoring and Management (XMM) platform purpose-built for midsized MSPs and internal IT teams. The unified platform integrates RMM (endpoint management), professional services automation (PSA), and Microsoft 365 multi-tenant management to help organizations simplify operations, strengthen security, and scale profitably. Syncro delivers powerful automation, native AI capabilities, deep Microsoft 365 integration, and seamless support for 50+ third-party tools—enabling teams to reduce complexity, cut costs, and uncover new revenue opportunities. Its transparent per-user pricing model and commitment to continuous innovation make it an ideal solution for modern IT operations.Starting Price: $129 per user per month -
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Heimdal® Endpoint Detection and Response is our proprietary multi-solution service providing unique prevention, threat-hunting, and remediation capabilities. It combines some of the most advanced threat-hunting technologies: - Next-Gen Antivirus - Privileged Access Management - Application Control - Ransomware Encryption Protection - Patch & Asset Management - Email Security - Remote Desktop - Threat Prevention ( DNS based ) - Threat Hunting & Action Center With 9 modules working together seamlessly under one convenient roof, all within one agent and one platform, Heimdal Endpoint Detection and Response grants you access to all the essential cybersecurity layers your business needs to protect itself against both known and unknown online and insider threats. Our state-of-the-art product empowers you to quickly and effortlessly respond to sophisticated malware with stunning accuracy, protecting your digital assets and your reputation in the process as well.Starting Price: $0/month
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Avast Business Hub
Avast
The Business Hub is an integrated, cloud-based security platform for businesses and IT service providers to manage all Avast Business solutions deployed in their networks. It provides real-time visibility of threats, comprehensive reporting, and management capabilities, all from a single pane of glass. Formerly known as CloudCare, the Business Hub is an easy-to-use cloud security platform with a refreshing new UI.Starting Price: $36.99 -
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Malwarebytes
Malwarebytes
Crushes cyberthreats. Restores confidence. Traditional antivirus simply doesn't cut it anymore. Malwarebytes crushes the latest threats before others even recognize they exist. We block viruses, malware, malicious websites, ransomware, and hackers that traditional antivirus isn't smart enough to stop. Our cutting-edge protection and response solutions are used by organizations of all sizes around the world. Traditional antivirus fails because it’s slow to react to new threats. And, well, because it’s “dumb.” We use layers of technology like anomaly detection (a cool sort of artificial intelligence), behavior matching, and application hardening to crush malware that hasn’t even been seen before. Alright, so not really like traditional antivirus. Premium protection and privacy for your home computers and devices. Enterprise-grade protection and remediation for organizations large and small.Starting Price: $47.22 per user per year -
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Uncover the unknown in your network with this EDR solution. This endpoint detection and response tool leverages ESET's multilayered Endpoint Protection Platform. All layers send relevant data to ESET Enterprise Inspector, which analyzes vast amounts of real-time endpoint data. Provides quick analysis and remediation of any security issue in the network. ESET Enterprise Inspector provides a unique behavior and reputation based detection that is fully transparent to security teams. All rules are easily editable via XML to allow fine-tuning. New rules can be created to match the needs of specific enterprise environments, including SIEM integrations. Utilize ESET’s endpoint detection and response tool to easily suppress false alarms by adjusting the sensitivity of detection rules for different computer groups or users. Combine criteria such as file name/path/hash/command line/signer to fine-tune the trigger conditions.Starting Price: $38 per user per year
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CrowdStrike Falcon
CrowdStrike
CrowdStrike Falcon is a cloud-native cybersecurity platform that provides advanced protection against a wide range of cyber threats, including malware, ransomware, and sophisticated attacks. It leverages artificial intelligence (AI) and machine learning to detect and respond to threats in real time, offering endpoint protection, threat intelligence, and incident response capabilities. The platform uses a lightweight agent that continuously monitors endpoints for signs of malicious activity, providing visibility and protection without significant impact on system performance. Falcon’s cloud-based architecture ensures fast updates, scalability, and rapid threat response across large, distributed environments. Its comprehensive security features help organizations prevent, detect, and mitigate potential cyber risks, making it a powerful tool for modern enterprise cybersecurity. -
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Acronis Cyber Protect
Acronis
Managing cyber protection in a constantly evolving threat landscape is a challenge. Safeguard your data from any threat with Acronis Cyber Protect (includes all features of Acronis Cyber Backup) – the only cyber protection solution that natively integrates data protection and cybersecurity. - Eliminate gaps in your defenses with integrated backup and anti-ransomware technologies. - Safeguard every bit of data against new and evolving cyberthreats with advanced MI-based protection against malware. - Streamline endpoint protection with integrated and automated URL filtering, vulnerability assessments, patch management and moreStarting Price: $85 -
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ConnectWise Cybersecurity Management
ConnectWise
Define and Deliver Comprehensive Cybersecurity Services. Security threats continue to grow, and your clients are most likely at risk. Small- to medium-sized businesses (SMBs) are targeted by 64% of all cyberattacks, and 62% of them admit lacking in-house expertise to deal with security issues. Now technology solution providers (TSPs) are a prime target. Enter ConnectWise Cybersecurity Management (formerly ConnectWise Fortify) — the advanced cybersecurity solution you need to deliver the managed detection and response protection your clients require. Whether you’re talking to prospects or clients, we provide you with the right insights and data to support your cybersecurity conversation. From client-facing reports to technical guidance, we reduce the noise by guiding you through what’s really needed to demonstrate the value of enhanced strategy. -
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Trend Vision One
Trend Micro
Stopping adversaries faster and taking control of your cyber risks starts with a single platform. Manage security holistically with comprehensive prevention, detection, and response capabilities powered by AI, leading threat research and intelligence. Trend Vision One supports diverse hybrid IT environments, automates and orchestrates workflows, and delivers expert cybersecurity services, so you can simplify and converge your security operations. The growing attack surface is challenging. Trend Vision One brings comprehensive security to your environment to monitor, secure, and support. Siloed tools create security gaps. Trend Vision One serves teams with these robust capabilities for prevention, detection, and response. Understanding risk exposure is a priority. Leveraging internal and external data sources across the Trend Vision One ecosystem enables greater command of your attack surface risk. Minimize breaches or attacks with deeper insight across key risk factors. -
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Cybereason
Cybereason
Together we can end cyber attacks at the endpoint, across the enterprise, to everywhere the battle moves. Cybereason delivers over-the-horizon visibility and high fidelity convictions of both known and unknown threats so defenders can leverage the power of true prevention. Cybereason provides the deep context and correlations from across the whole of the network to uncover stealthy operations and enable defenders to be expert threat hunters. Cybereason significantly reduces the time required for defenders to investigate and resolve attacks through both automated and guided remediation with just a click of the mouse. Cybereason analyzes 80 million events per second - that’s 100x the volume of other solutions on the market. Reduce investigation time by as much as 93% to eliminate emerging threats in a matter of minutes rather than days. -
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SanerNow
SecPod Technologies
SecPod SanerNow is the world's best unified endpoint security & management platform that powers IT/Security Teams automate cyber hygiene practices. It works on an intelligent agent-server model to execute effective endpoint management and security. It gives you accurate vulnerability management with scanning, detection, assessment, prioritization, and remediation capabilities. SanerNow is available on both cloud and on-premise, whose integrated patch management automates patching across all major OSs like Windows, MAC, Linux, and a vast collection of 3rd party software patches. What makes it unique? You can now access other salient features like security compliance management, IT asset management, endpoint management, software deployment, application & device control, and endpoint threat detection and response, all on a single platform. With SanerNow, you can remotely perform and automate these tasks to secure your systems from the emerging wave of cyberattacks.Starting Price: $50/year/device -
20
JumpCloud
JumpCloud
JumpCloud® delivers a unified open directory platform that makes it easy to securely manage identities, devices, and access across your organization. With JumpCloud, IT teams and MSPs enable users to work securely from anywhere and manage their Windows, Apple, Linux, and Android devices from a single platform. Everything in One Platform Grant users Secure, Frictionless Access™ to everything they need to do their work however they choose. Manage it all in one unified view. Cross-OS Device Management Manage Windows, macOS, Linux, iOS, iPad, and Android devices. One Identity for Everything Connect users to thousands of resources with one set of secure credentials. Comprehensive Security Enforce device policies, patches, MFA, and other security and compliance measures. Automated Workflows Connect to whatever resources you need, including Microsoft Active Directory, Google Workspace, HRIS platforms, and more.Starting Price: $9/user -
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ESET PROTECT
ESET
Protect your company endpoints, business data and users with ESET's multilayered technology. ESET PROTECT platform offers customizable security solutions, easy to manage from a cloud console. Cyber risk management and visibility into your IT environment. Stay one step ahead of any known or unknown threats. Up-to-date information and customized notifications allow the IT staff to react promptly to any risks that may have developed. Smart predefined policies and automated tasks help IT admins save time and better protect against future attacks. Easily meet reporting requirements and save time with scheduled reporting and dozens of customizable templates. A user within your network might open a malicious email containing a new form of ransomware. Programmers who work with code on their work computers might tend to create false positives due to compiling software.Starting Price: $239 per year -
22
Xcitium
Xcitium
Xcitium is the only unified zero-trust cybersecurity platform, bringing zero-trust posture all the way from endpoints to the cloud under a single pane of glass. With Xcitium, we protect with detection-less innovation: patented Kernel-level API virtualization. Xcitium reduces the amount of time a threat can maneuver or dwell in your environment, down to absolute zero. Attacks happen in minutes and seconds. However, the impact of an attack does not always occur instantly. It can take some dwell time for an intruder to get a foothold and to execute search and destroy or exfiltration missions. Xcitium intercepts and isolates the attack before any of its impact and intended damage can occur. Equip every endpoint, network, and workload with the latest threat intelligence against cyber threat signatures and payloads. Defense against new or zero-day cyber threats using powerful static, dynamic, and patented behavioral AI. -
23
Fortinet
Fortinet
Fortinet is a global leader in cybersecurity solutions, known for its comprehensive and integrated approach to safeguarding digital networks, devices, and applications. Founded in 2000, Fortinet provides a wide range of products and services, including firewalls, endpoint protection, intrusion prevention systems, and secure access solutions. At the core of its offerings is the Fortinet Security Fabric, a unified platform that seamlessly integrates security tools to deliver visibility, automation, and real-time threat intelligence across the entire network. Trusted by businesses, governments, and service providers worldwide, Fortinet emphasizes innovation, scalability, and performance, ensuring robust defense against evolving cyber threats while supporting digital transformation and business continuity. -
24
Check Point Harmony Endpoint
Check Point Software Technologies
Check Point Harmony is the industry’s first unified security solution for users, devices and access. The solution protects devices and internet connections from the most sophisticated attacks while ensuring Zero-Trust Access to corporate applications. Protecting today’s hyper-distributed workspace requires endless security functions across user devices, applications and networks. However, stitching together point solutions often leaves security gaps and creates a cumbersome infrastructure that is difficult to manage and scale. Harmony offers an alternative that saves you the overhead and increases security. Harmony unifies 6 cloud-based security products to keep you 100% safe. Wherever you connect from, whatever you connect to, and however you connect – Your home, your devices, your privacy and your organizational data are secured and protected from any cyber threat. -
25
BroShield
BroShield
If you want to free your system with unwanted snoop ware then BroShield should be your 1st choice as this provides you a great anti snooping and detection of harmful viruses from your computer. Protect your computer with BroShield protection. BroShield helps you to get full authority over the internet. You can keep an eye on what kind of content your kid is exposed to. Restriction of adult websites and harmful content is in your hand. Allows you to control the internet access time. There are a lot of illegal websites that still run on the internet. We need to restrict our kids from getting exposed to sites like porn, gambling, and inappropriate sites. Visiting such sites may bring in viruses and other unwanted things with it. BroShield runs 24/7 to look for viruses and threats and keep the computer in full monitoring, to block the potential threats. The smart feature of BroShield fail-safe is designed to look for all the remote snooping activities to prevent getting compromised.Starting Price: $49.95 per year -
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Guardio
Guardio
Forget all about malware, phishing, and identity theft. Guardio is a lightweight extension designed to help you browse quickly and securely. It will clean your browser, speed it up, and protect your private information. How it works. Add in seconds. Remove threats. Browse as usual. Cleans the way you see the web. Removes malware, unwanted popups, and any other annoyances that ruin your day. Protects against online threats. Blocks phishing, malicious sites and scams that may result in identity theft or worse - so you can focus on what matters. Keeps your secrets secret. Be notified when personal data leaks publicly and fortify your accounts with security best practices. Under the hood. Dive deeper into the powerful technology powering Guardio. Safe web, Great technology. In order to effectively combat emerging threats from ever-evolving malicious actors, Guardio needs to stay on the bleeding edge of multiple technology disciplines. Machine Learning, Big Data, Cloud InfrastructureStarting Price: $9.99 per month -
27
Apozy Airlock
Apozy
Apozy Airlock. The browser endpoint detection and response platform that neutralizes web attacks in one click. The Internet is a dangerous place. It doesn’t have to be. Airlock fills the gap in your EPP/EDR by protecting the browser, delivering a safe, clean, and lightning-fast internet experience. Powered by the very first visually-aware native browser isolation platform with over 6 petabytes of visual data, Airlock prevents web attacks in real time. Airlock stops spearfishing in its tracks. With a visual model database of over 67.83 billion pages which analyzes over 12.20 trillion links per year, our technology protects anyone clicking on a malicious link by sandboxing the threat.Starting Price: $9/month/user -
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KernelCare Enterprise
TuxCare
Global organizations trust TuxCare for live patching their critical Linux hosts and OT devices across their hybrid multi-cloud environments. No reboot is required to deploy and enable the TuxCare KernelCare Enterprise solutions to live patch Linux kernels and critical system libraries, including OpenSSL and Glibc. In contrast, all hosts and devices maintain the current production level uptime while receiving all security updates. TuxCare automates the patching process and eliminates the need to wait weeks or months for reboot cycles to apply patches. TuxCare currently protects over 1 million workloads worldwide. Tight integrations with popular patch management and vulnerability scanners, including Qualys, Crowdstrike, and Rapid7, enable TuxCare to fit seamlessly into existing infrastructure. The TuxCare secure patch server, ePortal, allows operations in gated and air-gapped environments. Reduce risk by significantly reducing the mean time to patch vulnerabilitiesStarting Price: $3.95 per month -
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Defense.com
Defense.com
Take control of cyber threats. Identify, prioritize and track all your security threats with Defense.com. Simplify your cyber threat management. Detection, protection, remediation, and compliance, are all in one place. Make intelligent decisions about your security with automatically prioritized and tracked threats. Improve your security by following the effective remediation steps provided for each threat. Gain knowledge and advice from experienced cyber and compliance consultants when you need assistance. Take control of your cyber security with easy-to-use tools that can work with your existing security investment. Live data from penetration tests, VA scans, threat intelligence and more all feeds into a central dashboard, showing you exactly where your risks are and their severity. Remediation advice is included for each threat, making it easy to make effective security improvements. Powerful threat intelligence feeds are mapped to your unique attack surface.Starting Price: $30 per node per month -
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Keplersafe
Keplersafe
All-in-one security with 1-click resolve that protects your entire business. A unified threat protection solution designed to bring you cutting-edge, holistic defense with zero drain on your IT resources. Our AI anticipates risk, then proactively identifies and addresses issues automatically, saving you valuable time. Keplersafe is the complete solution that makes it easy to be compliant for mid-market businesses with any sized IT or security team by helping to ensure you're protected according to best practices and accepted industry standards. The Keplersafe platform is built on the principle of holistic, non-disruptive security. Our platform employs innovative AI technology and behavioral analysis to assist businesses in staying secure and compliant, without IT teams having to worry, investigate or fix issues themselves. Keplersafe is based in New York City, with Sales and R&D offices around the globe.Starting Price: $8.99 per month
