Figure 3: Assessment of CRM activity in function of TF binding.
From: High-throughput and quantitative assessment of enhancer activity in mammals by CapStarr-seq
(a) Average binding profiles of indicated TFs in DP thymocytes for the inactive, weak and strong CRMs defined in P5424 cells. Statistically significant differences calculated on the regions highlighted in grey are indicated (P<0.05; Mann–Whitney U-test). (b) Enrichment of the inactive, weak and strong CRM sets in function of the number of different TFs bound. The enrichment score was calculated as the inverted Log10 of the P values obtained with a hypergeometric test. Statistically significant enrichments (P<0.001) are indicated by a dotted line.
