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Haematopoiesis refers to the commitment and differentiation processes that lead to the formation of all blood cells from haematopoietic stem cells. In adults, haematopoiesis occurs mainly in the bone marrow (medullary), but it can also occur in other tissues such as the liver, thymus and spleen (extramedullary).
Rearrangement of the B cell receptor is sequential, and pairing of the successfully assembled heavy chain with the surrogate light chain proteins VpreB and λ5 to form the pre-B cell receptor is an important checkpoint signal for continued B cell development. Here, the authors show that λ5 plays a key role in the multi-step assembly process involving association-induced folding reactions.
Alternative splicing greatly expands the transcriptomic and proteomic diversity in vertebrates. Here, the authors develop a machine-learning tool to identify functional splicing events during hematopoietic cell differentiation, revealing new regulators of hematopoiesis.
A CRISPR screen reveals that loss of structural components of the SAGA complex derails hematopoiesis by decoupling epigenetic control. This halts stem cell maturation, triggers a pathogenic interferon program and boosts human MDS-L cell growth.
The Carta algorithm infers a differentiation map — including progenitor cell types and transitions between progenitor and terminal cell types — from high-throughput lineage tracing data. Applying Carta to mouse hematopoiesis and embryoid developmental datasets reveals new intermediate progenitors and a secondary origin for a specialized cell type.
A new study uncovers how UBA1 mutations in VEXAS syndrome simultaneously promote myeloid inflammatory cell death and skew haematopoietic stem cells towards a myeloid lineage.
Early-life differentiation of self-reactive thymocytes into the regulatory T (Treg) cell lineage is crucial for lifelong immune tolerance to self. Reduced ZAP70 expression is now revealed as a key thymocyte-intrinsic selector of the neonatal Treg cell repertoire.
Cross-species analysis of thymic stroma in mice and humans reveals a subset of mesenchymal cells that are capable of restoring thymic function, which suggests new strategies for thymus regeneration.
